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Recent Imbruvica Approval Indicates CLL is Moving Towards Cure

Imbruvica is now approved to treat CLL (Chronic Lymphoid Leukemia) patients regardless of their history of treatment (treatment-naïve and previously-treated patients). Furthermore, Imbruvica is approved to treat CLL patients at high-risk with del 17p, a genetic aberration that occurs when part of chromosome 17, the location of the tumor suppressor gene p53, has been lost or removed.

WHAT IS CLL

CLL is a slow-growing #bloodcancer, which often arises from B cells, a type of white blood cells (lymphocyte) which originates in the bone marrow, CLL is predominantly a disease of the elderly, with a median age of 71 years at diagnosis.

About IMBRUVICA

#IMBRUVICA works by blocking a specific protein called Bruton’s tyrosine kinase (BTK). The BTK protein sends important signals that tell B cells to mature and produce antibodies and is needed by specific cancer cells to multiply and spread, IMBRUVICA targets and blocks BTK, inhibiting the survival of cancer cells and spread.

KEYTRUDA is approved for Patients with Recurrent or Metastatic Head and Neck Cancer

#Keytruda is approved at a fixed dose of 200 mg formulation of #Pembrolizumab administered every 3 weeks for the treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).

To evaluate the safety Keytruda, researchers enrolled 192 patients with metastatic or recurrent HNSCC and ECOG performance status zero or 1. Efficacy was assessed in 174 out of the patients who had progression of disease or after the platinum-containing chemotherapy is administered on metastatic or recurrent HNSCC, or after the platinum-containing chemotherapy is administered as part of the induction, concurrent or adjuvant therapy.

Ninety- five percent of the patients enrolled underwent prior radiation therapy , with a median number of prior treatment lines for HNSCC is 2. Participants received 10 mg / Hg Keytruda every 2 weeks (n = 53 ) or 200 mg fixed dose every 3 weeks ( n = 121 ) until disease progression or unacceptable toxicity occurred disease.

Merck’s KEYTRUDA is a humanized monoclonal antibody that works by increasing the ability of the body’s immune system to help detect and fight tumor cells, by blocking the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells.

Merck drug Keytruda is effective against below cancers :-

Melanoma – Keytruda is indicated for the treatment of patients with unresectable or metastatic melanoma at a dose of 2 mg/kg every three weeks.

Lung Cancer – Keytruda is indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors express PD-L1 as determined by an FDA-approved test with disease progression on or after platinum-containing chemotherapy, at a dose of 2 mg/kg every three weeks.

Head and Neck Cancer – Keytruda is indicated for the treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) with disease progression on or after platinum-containing chemotherapy at a fixed dose of 200 mg every three weeks.

Content Source: Drugs.com

Approximate Price for 4 vials of KEYTRUDA 50 mg is $8788.00

Has a generic version of Lysodren been approved?

#Lysodren is available only as a brand name drug, presently there is no therapeutic equivalent version of Lysodren is available in the United States.

The cost for Lysodren 500 mg tablet is about $516 for a supply of 100 tablets, depending on the pharmacy you visit.

Manufacturer : BRISTOL MYERS SQUIBB

 

Uses For Lysodren

#Mitotane used for the treatment of #AdrenalCancers. The adrenal glands produce hormones that are necessary for the body to cope with stress, fight infection and maintain normal functions such as blood pressure. Some types of cancer cause the adrenal glands produce too much cortisol and other hormones that cause a certain serious disease ( Cushing’s syndrome).
Excessive amounts of these hormones can cause many problems such as changes in blood pressure, weight changes, muscle / bone weakness, skin thinning, and diabetes. Mitotane works by killing or slowing the growth of the adrenal cells, and changes the adverse effects caused by too much hormone production.

Side Effects

Dizziness, drowsiness, nausea, diarrhea, loss of appetite, headache, or unusual weakness can occur. If these effects persist or worsen, notify your doctor immediately.

Tell your doctor immediately if you have any serious side effects

Proper Use of Lysodren

 

#Medicines used to treat #cancer are very strong and can have many side effects. Before taking this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

 

 

TAGRISSO (Osimertinib) Information –

FDA approved: Yes (First approved November 13th, 2015)
Brand name: Tagrisso
Generic name: Osimertinib
Company: AstraZeneca Pharmaceuticals LP
Treatment for: Non-Small Cell Lung Cancer

What is Tagrisso and what is it used for?

Tagrisso (osimertinib) is a tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR) which is used for the treatment of patients with metastatic EGFR T790M mutation-positive non-small cell #lungcancer whose disease has worsened on or after EGFR-TKI therapy.

Approximate Price for 30 tablets of Tagrisso 80mg is $13,468.80, depending on the pharmacy you visit.

 

How does Tagrisso work?

The EGFR gene is a protein involved in the growth and spread of cancer cells. EGFR tyrosine kinase inhibitors (EGFR-TKIs) are targeted treatments for non-small cell lung cancer, but tend to develop resistance over time, often as the result of EGFR mutations. Tagrisso is an EGFR-TKI that works against cells with the T790M mutation, one of the primary causes of EGFR resistance.

Tagrisso Dosing Information :-

Take Tagrisso exactly as prescribed by your doctor.

Duration of therapy: Until disease progression or unacceptable toxicity

What are the common Side-Effects?

The most common side effects of Tagrisso include diarrhea, and skin and nail conditions such as dry skin, rash and infection or redness around the fingernails. Tagrisso may cause serious side effects including interstitial lung disease (ILD)/pneumonitis, QTc interval prolongation and cardiomyopathy.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Warnings And Precautions :-

You should not use Tagrisso if you are allergic to osimertinib.

To make sure Tagrisso is safe for you, tell your doctor if you have:

  • a breathing disorder;
  • an electrolyte imbalance (such as high or low levels of calcium, potassium, or magnesium in your blood);
  • a heart rhythm disorder; or
  • a personal or family history of long QT syndrome.
  • Tagrisso can harm an unborn baby or cause birth defects. Do not use if you are pregnant, and tell your doctor right away if you become pregnant.
  • It is not known whether osimertinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine and for at least 2 weeks after your last dose.
  • If a man fathers a baby while using Tagrisso, the baby may have birth defects.
  • This medicine may affect fertility (your ability to have children), whether you are a man or a woman. However, you should use birth control as recommended during and after treatment with Tagrisso.

What other drugs will affect Tagrisso?

Many drugs can interact with osimertinib. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

    • an antidepressant;
    • cancer medicine;
    • an antibiotic or antifungal medicine;
    • antiviral medicine to treat hepatitis or HIV/AIDS;
    • heart or blood pressure medicine;
    • medicine to treat a psychiatric disorder;
    • seizure medicine; or
    • tuberculosis medicine.

This list is not complete and many other drugs can interact with Tagrisso. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

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