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WHAT IS CERITINIB?
Ceritinib is a targeted therapy. It is an oral tyrosine kinase inhibitor. Ceritinib is a targeted therapy that targets and binds to the tyrosine kinase receptors and inhibits ALK, insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (InsR), and ROS1on the surface of the cell. By binding to these receptors ceritinib blocks an important pathway that promotes cell division.
Ceritinib is used to treat non-small cell lung cancer caused by a defect in a certain gene. Ceritinib is used when the cancer has spread to other parts of the body. Ceritinib is usually given after other cancer medicines have been tried without success.
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
slow heartbeats, weak pulse, weak or shallow breathing; headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
severe stomach pain, ongoing nausea or vomiting; sudden chest pain or discomfort, fever, dry cough or cough with mucus, feeling short of breath;
easy bruising or bleeding (nosebleeds, bleeding gums); signs of pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss.
Common side effects may include:
stomach pain, loss of appetite; nausea, vomiting; diarrhea, constipation; tired feeling; or abnormal liver tests (high liver enzyme levels).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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