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WHAT IS TEMOZOLOMIDE?
Temozolomide interferes with the development of cancer cells, slowing their growth and spread in the body. Temozolomide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "alkylating agent."
Temozolomide is used for the treatment of anaplastic astrocytoma, glioblastoma multiforme (GBM) (types of brain tumors). Temozolomide is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific. Temozolomide is similar to the drug dacarbazine. It acts as a "pro-drug" meaning it needs to be transformed to its active (cancer fighting) form by the body's metabolism.
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
seizure (convulsions); fever, chills, dry cough, feeling short of breath;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
bruising, skin rash; loss of movement on one side of the body; nausea, vomiting, loss of appetite;
diarrhea, constipation; headache, tired feeling, memory problems; dizziness, weakness, loss of coordination;
sleep problems (insomnia); low white blood cell counts (fever, flu symptoms); or hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Store in a tightly closed container between 2-8°C.