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WHAT IS TRABECTEDIN?
Trabectedin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Trabectedin is classified as an "alkylating agent." Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific. There are several types of alkylating agents classified according to the substances with which they interfere.
Trabectedin is used to treat liposarcoma, a rare type of cancer that grows in fatty tissues of the body. Trabectedin is also used to treat leiomyosarcoma, a rare fast-growing type of cancer that grows in many tissues of the body, including fat, muscle, bone, joints, and blood vessels. Trabectedin is used to treat cancer that has spread to other parts of the body or cannot be treated with surgery.
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pain, burning, irritation, or skin changes where the injection was given;
heart problems--chest pain, fast or pounding heartbeats, shortness of breath (even with mild exertion), swelling, rapid weight gain;
breakdown of muscle tissue--unexplained muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine);
liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling tired or light-headed.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
nausea, vomiting, loss of appetite; diarrhea, constipation; abnormal liver or kidney function tests; headache; or feeling short of breath.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Drug vials should be stored in a refrigerator at 2 to 8 degrees Celsius (36 to 46 Fahrenheit).