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WHAT IS DACTINOMYCIN?
Dactinomycin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "antitumor antibiotic." Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. "Normal" cells stop dividing when they come into contact with like cells, a mechanism known as contact inhibition. Cancerous cells lose this ability.
Dactinomycin is used to treat Wilms' tumor, Childhood Rhabdomyosarcoma, Ovarian (germ cell) cancer, Gestational trophoblastic neoplasm, Ewing's sarcoma, Metastatic testicular tumors (nonseminoatous), Gestational trophoblastic neoplasm, Locally recurrent or locoregional solid tumors (sarcomas, carcinomas and adenocarcinomas), Soft tissue sarcoma and Osteosarcoma.
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pain, swelling, burning, irritation, or skin changes where the injection was given; fever, chills, body aches, diarrhea, flu symptoms, sores in your mouth and throat;
swelling or tenderness in your upper stomach, weight gain, dark urine, jaundice (yellowing of the skin or eyes);
feeling short of breath, urinating less than usual or not at all; chest pain, dry cough, wheezing; pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
any wound that will not heal; or redness or your skin or the inside of your mouth and throat (if you are also receiving radiation treatment).
Common side effects may include:
nausea, vomiting, stomach pain, loss of appetite; tired feeling, muscle pain; rectal pain or bleeding; numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes; hair loss; dry or cracked skin, chapped lips; or acne, mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Protect from light and humidity.