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WHAT IS RUXOLITINIB ?
Ruxolitinib is a targeted therapy. It is an oral receptor tyrosine kinase inhibitor. Ruxolitinib works by blocking certain enzymes in the body that affect blood cell production. Ruxolitinib is a targeted therapy that targets and binds to the tyrosine kinase receptors and inhibits Janus Associated Kinases which mediate the signaling of a number of cytokines and growth factors that are important for hematopoiesis and immune function. By binding to these receptors, ruxolitinib blocks important pathways that promote cell division.
Ruxolitinib is used to treat myelofibrosis or polycythemia vera, which are bone marrow disorders that affect your body's ability to produce blood cells. Do not change your dose or stop ruxolitinib unless your health care provider tells you to.
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may be similar to the symptoms of myelofibrosis. Call your doctor at once if you have a serious side effect such as:
pain or burning when you urinate; nausea, vomiting, weakness; blisters or painful skin rash; unusual pain or general ill feeling;
changes in the size, shape, or color of a mole or skin lesion; low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
low platelets--easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing.
Common side effects may include:
anemia; low platelets (easy bruising); dizziness; or headache.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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