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WHAT IS IMATINIB MESYLATE ?
Imatinib Mesylate is a targeted therapy. Imatinib Mesylate is classified as a signal transduction inhibitor - protein-tyrosine kinase inhibitor. Imatinib mesylate belongs to the signal transduction inhibitor category of targeted therapies. It is particularly a protein-tyrosine kinase inhibitor.
Imatinib Mesylate is used for Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase. Ph+ CML in blast crisis, accelerated phase, or chronic phase after failure of interferon-alpha therapy. Adult patients with relapsed or refractory Philadelphia chromosome + acute lymphoblastic leukemia (Ph+ ALL). Adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with PDGFR gene rearrangements. Gastrointestinal stromal tumors that are C-kit positive.
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fluid retention--shortness of breath (even while lying down), swelling, rapid weight gain (especially in your face and midsection); fluid build-up in the lungs--pain when you breathe, wheezing, gasping for breath, cough with foamy mucus;
liver problems--upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
signs of tumor cell breakdown--lower back pain, blood in your urine, little or no urinating; numbness or tingly feeling around your mouth; muscle weakness or tightness; fast or slow heart rate, weak pulse; confusion, fainting; thyroid symptoms--extreme tired feeling, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cold temperatures; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
nausea, vomiting, stomach pain, diarrhea; joint or muscle pain; skin rash; or feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [See USP Controlled Room Temperature]. Protect from moisture.