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WHAT IS BENDAMUSTINE?
Bendamustine is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Bendamustine is classified as an "alkylating agent. Bendamustine is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell-cycle. There are several types of alkylating agents. Bendamustine is a nitrogen mustard derivative and is active against resting as well as dividing cells.
Bendamustine is used for treatment of chronic lymphocytic leukemia (CLL). Bendamustine is also used for the treatment of patients with indolent B-cell non-Hodgkin's lymphoma.
POSSIBLE SIDE EFFECTS:
Some people receiving a bendamustine injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you have fever, chills, itching, or skin rash during or shortly after the injection.
Get emergency medical help if you have any signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have:
severe ongoing nausea, vomiting, or diarrhea; feeling very weak or tired; cough with yellow or green mucus, stabbing chest pain, wheezing, feeling short of breath; pain, swelling, redness, skin changes, or signs of infection where the medicine was injected;
low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;
signs of tumor cell breakdown--lower back pain, blood in your urine, little or no urination; numbness or tingly feeling around your mouth; muscle weakness or tightness; fast or slow heart rate, weak pulse, confusion, fainting;
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling; or
severe skin reaction--swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
fever, cough, mouth sores; nausea, vomiting, diarrhea, constipation; headache, tiredness, dizziness, drowsiness;
swelling in your hands or feet; loss of appetite, weight loss; or mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Store intact vials between 2°C to 8°C (36°F to 46°F); protect from light.