What is Zykadia?

#Zykadia (Ceritinib) is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Zykadia is used to treat non-small cell #lungcancer caused by a defect in a certain gene. It is used when the cancer has spread to other parts of the body. Zykadia is usually given after other cancer medicines have been tried without success.


Precautions Before Taking Zykadia

You should not use Zykadia if you are allergic to ceritinib.

To make sure Zykadia is safe for you, tell your doctor if you have:

  • congestive heart failure;
  • a heart rhythm disorder, or long QT syndrome;
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
  • a pancreas disorder;
  • diabetes or high blood sugar; or
  • liver disease.

Do not use Zykadia if you are pregnant. It could harm the unborn baby. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine and for at least 2 weeks after your treatment ends.

It is not known whether #ceritinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Zykadia.

Side-Effects of Zykadia

Get emergency medical help if you have any of these signs of an allergic reaction to Zykadia: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • slow heartbeats, weak pulse, weak or shallow breathing;
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • severe diarrhea;
  • severe stomach pain, ongoing nausea or vomiting;
  • sudden chest pain or discomfort, fever, dry cough or cough with mucus, feeling short of breath;
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • signs of pancreatitis – severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • high blood sugar – increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss.

Common Zykadia side effects may include:

  • stomach pain, loss of appetite;
  • nausea, vomiting;
  • diarrhea, constipation;
  • tired feeling; or
  • abnormal liver tests (high liver enzyme levels).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What should I avoid while taking Zykadia?

Grapefruit and grapefruit juice may interact with ceritinib and lead to unwanted side effects. Avoid the use of grapefruit products while taking Zykadia.