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WHAT IS BORTEZOMIB?
Bortezomib is a targeted therapy. Bortezomib is classified as a proteasome inhibitor. Bortezomib interferes with the growth of some cancer cells and keeps them from spreading in your body. Bortezomib is sometimes given after other cancer medications have been tried without successful treatment.
Bortezomib is used to treat multiple myeloma and also for the treatment of mantle cell lymphoma who have received at least one prior therapy. Bortezomib targets and inhibits the proteasome enzyme complex within the cell. Proteasome is part of the cellular machinery and has many functions within the cell, such as it helps to control the level of many of the proteins that help to regulate cell division and cell survival. By interfering with it's function this can lead to apoptosis (cell suicide).
POSSIBLE SIDE EFFECTS:
Bortezomib may cause a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, or problems with speech or walking. These symptoms may start gradually and get worse quickly.
Also call your doctor at once if you have:
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
new or worsening cough, shortness of breath; new or worsening nerve problems such as numbness, burning, pain, weakness, or tingly feeling; pain, redness, bruising, tenderness, or a hard lump where the medicine was injected;
severe constipation; dehydration symptoms--muscle cramps, feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
high blood pressure--severe headache, pounding in your neck or ears, anxiety, irregular heartbeats;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or
signs of tumor cell breakdown--lower back pain, blood in your urine, little or no urinating; numbness or tingly feeling around your mouth; muscle weakness or tightness; fast or slow heart rate, weak pulse, feeling short of breath; confusion, fainting.
Common side effects may include:
numbness, tingling, or burning pain in your hands or feet; loss of appetite, nausea, vomiting; diarrhea, constipation, bloating; fever, chills, cold or flu symptoms; pale skin, easy bruising or bleeding; rash; or feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Prior to reconstitution, store intact vials at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F). Once reconstituted, the manufacturer recommends use within 8 hours of reconstitution.