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WHAT IS PAZOPANIB ?
Pazopanib is a type of biological therapy called a tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins which act as chemical messengers (enzymes) in cells. There are a number of different tyrosine kinases and they stimulate cancer cells to grow. Pazopanib blocks a number of these proteins and is called a multi tyrosine kinase inhibitor (multi TKI). It stops cancer cells forming blood vessels that they need in order to grow. This is called anti-angiogenesis treatment.
Pazopanib is a treatment for advanced kidney cancer (renal cancer). Pazopanib is also used to treat soft tissue sarcoma (a tumor that can develop in or around muscles, tendons, joints, organs, or blood vessels). Pazopanib is usually given after other cancer medications have been tried without successful treatment of soft tissue sarcoma.
POSSIBLE SIDE EFFECTS OF PAZOPANIB:
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using pazopanib and call your doctor at once if you have:
stomach pain or swelling, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
slow healing of a wound or surgical incision, or any wound that will not heal; headache, confusion, change in mental status, vision loss, seizure (convulsions);
sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath; signs of infection--fever, sore throat, cough, flu symptoms, body aches, skin sores;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
signs of other heart problems--feeling short of breath (even with mild exertion), swelling, rapid weight gain, headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs; or
dangerously high blood pressure - severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats, seizure.
Liver problems may be more likely in adults older than 65.
Common Votrient side effects may include:
nausea, vomiting, diarrhea; loss of appetite; or changes in hair color.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Store at room temperature between 20°C and 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F)
Glaxo Wellcome S.A,
Avenida de Extremadura 3, 09400 Aranda de Duero, Burgos, Spain.
IMPORTED AND MARKETED BY:
GlaxoSmithKline Pharmaceuticals Limited
Mumbai-400 030, India