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WHAT IS REGORAFENIB ?
Regorafenib works by blocking particular proteins on cancer cells that encourage the cancer to grow. These proteins are called protein kinases. Regorafenib is called a protein tyrosine kinase inhibitor (TKI) or cancer growth blocker. Regorafenib stops a number of different proteins being made and is called a multi kinase inhibitor. It works by stopping signals that tell cancer cells to grow. It also stops the cancer cells growing blood vessels that they need. Blocking blood vessel growth is called anti angiogenesis treatment.
Regorafenib is a treatment for bowel cancer that has spread to other parts of the body – when other treatments are no longer working or are unsuitable and gastro intestinal stromal cancer (GIST) – a rare type of soft tissue sarcoma of the stomach or intestines. This treatment is used when other treatments are no longer working or are unsuitable
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using regorafenib and call your doctor at once if you have:
headache, confusion, change in mental status, vision loss, seizure (convulsions);
chest pain and severe dizziness, fainting, feeling short of breath; a high fever with severe stomach pain or swelling; rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;
severe bleeding--heavy menstrual periods or abnormal vaginal bleeding, blood in your urine or stools, coughing up blood, or any bleeding that will not stop; signs of infection--fever, chills, flu symptoms, mouth sores, severe or ongoing vomiting or diarrhea;
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); dangerously high blood pressure--blurred vision, buzzing in your ears, anxiety, uneven heartbeats; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
nausea, diarrhea, stomach pain, loss of appetite, weight loss; infection; mouth or throat pain, hoarse voice; or feeling weak or tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Store tablets in the original bottle and protect from moisture (do not remove the desiccant); keep container tightly closed. Discard any unused tablets 7 weeks after opening the bottle.