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WHAT IS DENOSUMAB?
Denosumab is a monoclonal antibody that works as a RANK ligand (RANKL) inhibitor. This medications is classified as a "bone-modifying agent". Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.
Denosumab is used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. Xgeva is also used to treat giant cell bone tumor in adults and teenagers with fully matured bone structure. Xgeva is also used to treat high blood levels of calcium caused by cancer, when other medicines such as pamidronate or zoledronic acid have been used without success.
POSSIBLE SIDE EFFECTS:
Get emergency medical help if you have any of these signs of an allergic reaction: itching, rash, hives; difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
new or unusual pain in your thigh, hip, or groin; fast or slow heart rate, trouble breathing;
low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
low levels of calcium in your blood (hypocalcemia)--numbness or tingly feeling around your mouth or in your fingers or toes, muscle tightness or contraction, overactive reflexes.
Common side effects may include:
feeling weak or tired; nausea, vomiting, loss of appetite; diarrhea, constipation; headache, back pain; or
pain or swelling in your arms or legs.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Store in original carton at 2°C to 8°C (36°F to 46°F). Do not freeze. Prior to use, bring to room temperature of 25°C (77°F) in original container (usually takes 15 to 30 minutes); do not use any other methods for warming. Use within 14 days once at room temperature. Protect from direct heat and light; do not expose to temperatures >25°C (77°F). Avoid vigorous shaking.